has_role carboxylic acid non-steroidal anti-inflammatory drug EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor sulindac sulfone 0 372.08316 372.417 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=Cc1ccc(S(C)(=O)=O)cc1 CHEBI:64212 patent:US5696159 pubmed:17016604 wikipedia.en:Exisulind {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid drugcentral:3219 exisulind CiteXplore:21735687 CiteXplore:20332437 NCIt:C1239 cis-5-Fluoro-2-methyl-1-(p-methylsulfonylbenzylidenyl)indene-3-acetic acid cas:59973-80-7 InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- CiteXplore:21515355 5-Fluoro-2-methyl-1-((Z)-p-(methylsulfonyl)benzylidene)indene-3-acetic acid MESH:C025463 chebi_ontology patent:EP1336602 MVGSNCBCUWPVDA-MFOYZWKCSA-N Reaxys:7887099 C20H17FO4S pubmed:20374023 pubmed:21515355 pubmed:22364235 CiteXplore:17016604 A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor. CiteXplore:20374023 {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid ChemIDplus:59973-80-7 reaxys:7887099 ChEMBL:551936 patent:US5776962 pubmed:21735687 CiteXplore:22364235 pubmed:20332437