organic heterocyclic compound phenols carboxamide ivacaftor 0 392.20999 392.499 pubmed:22499233 Kalydeco ivacaftorum drugcentral:4228 reaxys:11821038 pubmed:22698459 C24H28N2O3 chebi_ontology pubmed:22618984 pubmed:22768130 pubmed:22543461 pubmed:22508750 pubmed:22383668 pubmed:22293084 An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-<em>tert</em>-butylphenol. Used for the treatment of cystic fibrosis. wikipedia.en:Ivacaftor cas:873054-44-5 VX-770 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide pubmed:22739718 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide pubmed:22723294 pubmed:22047557 ivacaftor CHEBI:66901 CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2cnc3ccccc3c2=O)cc1O PURKAOJPTOLRMP-UHFFFAOYSA-N kegg.drug:D09916 InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)