organic heterocyclic compound carboxamide trametinib 0 615.07788 615.403 N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide pubmed:23533766 JTP 74057 pubmed:23290787 trametinib pubmed:26119340 pubmed:23438367 pubmed:23248257 pubmed:23441129 patent:WO2011038085 pubmed:23035153 pubmed:34156985 drugcentral:4802 pubmed:34282746 pubmed:24055054 CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1 pubmed:23432625 pubmed:34145930 pubmed:22245957 pubmed:21523318 drugbank:DB08911 chebi_ontology reaxys:12497153 pubmed:34516041 pubmed:23709751 patent:WO2011047238 patent:WO2011038082 pubmed:23893461 pubmed:23807941 lincs.smallmolecule:LSM-1143 GSK 1120212 A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment. pubmed:23583440 pubmed:34421360 C26H23FIN5O4 pubmed:34034619 chemspider:9881833 pubmed:23649971 trametinibum pubmed:23846731 pubmed:23844038 pubmed:23977666 pmc:PMC7715110 pubmed:23658559 InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34) pubmed:34355652 cas:871700-17-3 kegg.drug:D10175 patent:WO2005121142 pubmed:34590600 pubmed:23237773 pubmed:23971497 pubmed:34484797 pubmed:33922284 CHEBI:75998 pubmed:34413035 pubmed:34592184 wikipedia.en:Trametinib N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide LIRYPHYGHXZJBZ-UHFFFAOYSA-N pubmed:23587417