organic heterocyclic compound carboxylic acid carboxamide dolutegravir 0 419.12928 419.384 A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4<i>R</i>,12a<i>S</i>)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2<em>H</em>-pyrido[1',2':4,5]pyrazino[2,1-<em>b</em>][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. pubmed:23824675 chebi_ontology pubmed:22878423 pdb-ccd:DLU pubmed:23798668 S/GSK1349572 pubmed:23807273 pubmed:23830355 reaxys:12732602 (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide pubmed:23413040 pubmed:23432922 pubmed:23777012 pubmed:23845180 C20H19F2N3O5 pubmed:23669385 (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide pubmed:23885999 kegg.drug:D10066 pubmed:23132334 pubmed:22018760 wikipedia.en:Dolutegravir InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1 [H][C@]12Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N1[C@H](C)CCO2 drugcentral:4805 cas:1051375-16-6 pubmed:24096683 pubmed:23225901 pubmed:22905856 patent:WO2006116764 RHWKPHLQXYSBKR-BMIGLBTASA-N pubmed:23455469 pubmed:23295935 patent:EP2602260 pubmed:23075918 pubmed:22205735 pubmed:23306000 pubmed:23942060 pubmed:24074642 pubmed:23817375 CHEBI:76010 pubmed:24052331