organic heterocyclic compound
paroxetine
0
329.14272
329.371
pubmed:17652957
pubmed:16395417
pubmed:17559097
pubmed:11819027
pubmed:14689334
[H][C@@]1(c2ccc(F)cc2)CCNC[C@H]1COc1ccc2c(c1)OCO2
pubmed:15853570
pubmed:22198456
pubmed:22212003
pubmed:11910269
pubmed:16913391
pubmed:14521492
pubmed:15963219
pubmed:15845695
pubmed:21909633
pubmed:11009210
(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
pubmed:15376524
CHEBI:7936
pubmed:19851065
pubmed:16397315
pubmed:15199661
pubmed:17874333
kegg.compound:C07415
pubmed:11360029
Paroxetine
pubmed:15048901
InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
pubmed:22240860
(3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
pubmed:11565622
pubmed:22153922
reaxys:7467879
pubmed:17612590
pubmed:18808757
pubmed:15374134
pubmed:22263916
pubmed:18273418
(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
pubmed:17122538
pubmed:14624192
(-)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine
pubmed:15903129
pubmed:21739267
pubmed:15992089
pubmed:12369443
pubmed:16765127
wikipedia.en:Paroxetine
pubmed:21939725
pubmed:12920419
kegg.drug:D02362
pubmed:18983224
pubmed:12818234
pubmed:17162096
pubmed:14566200
pubmed:11513198
lincs.smallmolecule:LSM-2843
pubmed:11324355
drugcentral:2068
pubmed:14619895
pubmed:21922171
paroxetinum
pubmed:22377745
pubmed:12027788
drugbank:DB00715
pubmed:11563413
pubmed:19687003
pubmed:16426087
pubmed:15544025
A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3<i>S</i>,4<i>R</i>)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT<small><sub>2A</sub></small>, 5-HT<small><sub>1A</sub></small>, D<small><sub>2</sub></small> or H<small><sub>1</sub></small> receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
pubmed:17286545
pubmed:12906023
pubmed:12088162
pubmed:15613191
pubmed:21404089
cas:61869-08-7
pubmed:16822276
pubmed:12820211
pubmed:11169163
pubmed:17219219
paroxetina
pubmed:14516531
pubmed:11271409
pubmed:14673053
pubmed:14566196
pubmed:21452176
pubmed:22353759
C19H20FNO3
pubmed:11893234
AHOUBRCZNHFOSL-YOEHRIQHSA-N
pubmed:17452166
pubmed:15264994
pubmed:11281965
pubmed:21908494
chebi_ontology
pubmed:12421645
pubmed:14978354
pubmed:18345955
pubmed:15241233
pubmed:22283559