has_role organic heterocyclic compound rofecoxib 0 314.06128 314.362 drugcentral:2397 A butenolide that is furan-2(5<em>H</em>)-one substituted by a phenyl group at position 3 and by a <em>p</em>-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke. C17H14O4S pubmed:10859630 Vioxx InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3 Ceoxx 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone SNOMEDCT:116095002 MESH:C116926 rofecoxibum cas:162011-90-7 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone RZJQGNCSTQAWON-UHFFFAOYSA-N 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one kegg.compound:C07590 Rofecoxib pubmed:11014111 kegg.drug:D00568 chebi_ontology pubmed:20162413 drugbank:DB00533 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 reaxys:8269007 pubmed:28166217 NCIt:C1832 rofecoxib CHEBI:8887 wikipedia.en:Rofecoxib pubmed:16934051 pubmed:12069696 SNOMEDCT:387008005 lincs.smallmolecule:LSM-2482 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one drug role