has_role lipid organic heterocyclic compound simvastatin 0 418.27192 418.574 wikipedia.en:Simvastatin Simvastatine beilstein:4768037 MK-733 pubmed:17640385 MESH:D019821 pubmed:14973129 pubmed:14691614 CHEBI:45577 lincs.smallmolecule:LSM-2492 cas:79902-63-9 pubmed:12827636 patent:EP33538 drugbank:DB00641 Simvastatina InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 CHEBI:9150 pubmed:14561068 pubmed:11336576 pubmed:16144183 A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate SNOMEDCT:387584000 patent:US4444784 pubmed:18936176 C25H38O5 hmdb:HMDB0005007 Simvastatinum SNOMEDCT:96304005 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one pubmed:22737247 Zocor kegg.drug:D00434 Simvastatin pubmed:18688862 pubmed:18199328 RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin drugcentral:2445 NCIt:C29454 [H][C@@]12C(=C[C@H](C)C[C@@H]1OC(=O)C(C)(C)CC)C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1 chebi_ontology (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate drug role