B cell transitional stage B cell An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen. T2 B cell Transitional stage B cells represent an intermediary stage in B cell development between immature B cells, which are produced within the bone marrow, and mature B cells, which circulate in the blood and peripheral lymphoid tissues. Transitional B cells migrate from the bone marrow to secondary lymphoid organs, usually the spleen. Transitional B cells may still undergo negative and positive selection processes to remove self-reactive B cells and to enhance survival and clonal expansion of antigen-specific cells, respectively. Transitional B cells can mature into either follicular B cells in the splenic follicles following tonic or strong B cell receptor (BCR) signaling and BAFF signaling, or marginal zone B cells between the red and white pulp of the spleen following weak BCR signaling and Notch2 signaling. Some transitional B cells themselves also possess regulatory B cell functions. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) transitional B cell T3 B cell https://cellxgene.cziscience.com/cellguide/CL_0000818 T1 B cell transitional stage B-cell transitional stage B lymphocyte ZFA:0009345 transitional stage B-lymphocyte This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'.