mature natural killer cell CD16-negative, CD56-bright natural killer cell, human https://cellxgene.cziscience.com/cellguide/CL_0000938 This cell type is compatible with the HIPC Lyoplate markers for 'CD16-CD56bright NK cell'. Markers are associated with human cell types. CD16-CD56bright NK cell CD56-bright cytokine secreting NK cell CD56-bright cytokine secreting natural killer cell NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic. The CD16-negative, CD56-bright natural killer (NK) cell is a subtype of human natural killer cells that plays a pivotal role in the innate immune response. These cells are identified primarily by the lack of CD16, a low-affinity receptor for the Fc region of immunoglobulins G, and high expression of CD56 protein, a neural cell adhesion molecule, on the cell surface. This unique receptor pattern characterizes the regulatory role of these cells in the immune system and distinguishes them from their counterparts - the CD16-positive, CD56-dim NK cells, which have cytotoxic killing actions instead. CD16-negative, CD56-bright NK cells are specialized in immunomodulation and this trait is manifested primarily through the release of substantial amounts of cytokines, including TNF, IFN-gamma, GM-CSF, and especially IL-10, when they interact with specific target cells or in response to stimulation by cytokines such as IL-12, IL-15, and IL-18. Thus, these cells form a significant link between innate and adaptive immunity. Furthermore, these cells have tropism for secondary lymphoid tissues, where they frequently interact with dendritic cells, contributing to the modulation of dendritic cell maturation and function. This intimate crosstalk between CD16-negative, CD56-bright NK cells and dendritic cells is crucial for the orchestration of both innate and adaptive immune responses. Hence, while the term 'natural killer cell' may suggest a primary role in cell killing, this particular subset of NK cells exert their effects mainly through immune regulation and interaction with other immune cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) CD16-negative, CD56-bright NK cell