myeloid cell pre-conventional dendritic cell 2010-01-19T03:39:30Z The pre-conventional dendritic cell (pre-cDC) are precursors of mature dendritic cells. They develop from common DC precursors in the bone marrow and exist in a semi-differentiated state. The term 'pre-conventional' denotes the stage of development of these cells prior to their maturation into conventional dendritic cells, which are critical players in immune responses. After leaving the bone marrow, pre-cDCs transiently circulate in the bloodstream to colonize lymphoid and non-lymphoid tissues, including skin, mucosa, spleen, and lymph nodes where they differentiate into immature conventional dendritic cells, which undergo further differentiation. In mouse and humans, the population of pre-cDCs has been shown to be heterogeneous with two subpopulations that pre-committed to differentiate into different subsets of dendritic cells (cDC1 and cDC2). These subsets of differentiated dendritic cells play a key role in the immune response by bringing about the regulation and initiation of T cell responses, thereby shaping the adaptive immunity. One subset is thought to be specialized in highly efficient activation of CD8+ T cells, while the other subset presents exogeneous antigens to CD4+ T cells. The main function of pre-conventional dendritic cells is to constantly replenish conventional dendritic cells. In response to infection additional pre-cDCs are recruited to the site of infection to meet increased tissue demand, and this pre-DC recruitment may be necessary for effective T cell responses. The molecular signals that direct pre-cDC migration remain poorly understood but recent research suggest that it involves specific chemokine receptors expressed on pre-cDCs. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha. https://cellxgene.cziscience.com/cellguide/CL_0002010 hematopoietic lineage restricted progenitor cell