classical monocyte CD14-positive, CD16-negative classical monocyte 2010-06-05T08:25:41Z This cell type is compatible with the HIPC Lyoplate markers for 'CD16- monocyte'. The markers used in the definition are associated with human monocytes. A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive. https://cellxgene.cziscience.com/cellguide/CL_0002057 CD16- monocyte CD16-negative monocyte CD14+ CD16- classical monocytes are a subtype of monocytes that form a crucial component of the human immune system. Emerging from the bone marrow and entering the bloodstream, these cells play central roles in immune responses and regulation of inflammation. They form the majority of circulating monocytes in the body, typically contributing to around 80-90% of the total monocyte pool. The primary function of these classical monocytes is to serve in the frontline of host defense against infections. They are primed to migrate to sites of infection, and they express pattern recognition receptors that help them identify and phagocytose pathogens, leading to their destruction. Classical monocytes also contribute to inflammation by producing several pro-inflammatory cytokines. In response to specific signals from tissues under pathological conditions, such as infection or injury, classical monocytes can leave the bloodstream and migrate towards the affected sites. Following their arrival, these cells differentiate into diverse cell types including macrophages and dendritic cells to combat specific pathogens or injury. Dysregulated monocyte activity can lead to the development of many human diseases including inflammation, infection, tissue injury, and various autoimmune diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)