GPI anchor biosynthetic process https://github.com/geneontology/go-ontology/issues/28227 https://github.com/geneontology/go-ontology/issues/30568 MetaCyc:PWY-8600 The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. MetaCyc:PWY-8601 GO:0006506 Reactome:R-HSA-162710 GPI/GSI anchor biosynthesis GPI anchor formation biological_process GPI anchor synthesis GPI anchor biosynthesis GPI/GSI anchor biosynthetic process GO:0015998 GPI anchor anabolism glycosylphosphatidylinositol biosynthesis glycosylphosphatidylinositol biosynthetic process lipid metabolic process organophosphate biosynthetic process carbohydrate derivative biosynthetic process