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    <!-- http://purl.obolibrary.org/obo/HP_0001646 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0001646">
        <rdfs:label>Abnormal aortic valve morphology</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/HP_0001647 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0001647">
        <rdfs:label>Bicuspid aortic valve</rdfs:label>
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        <oboInOwl:hasExactSynonym>Aortic valve has two leaflets rather than three</oboInOwl:hasExactSynonym>
        <ns4:IAO_0000115>The presence of an aortic valve with two instead of the normal three cusps (flaps). Bicuspid aortic valvue is a malformation of a commissure (small space between the attachment of each cusp to the aortic wall) and the adjacent parts of the two corresponding cusps forming a raphe (the fused area of the two underdeveloped cusps turning into a malformed commissure between both cusps; the raphe is a fibrous ridge that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps).</ns4:IAO_0000115>
        <rdfs:comment>A normal aortic valve is composed of three aortic-valve cusps, each semilunar in appearance. The leaflets are housed within a small dilatation of the proximal aorta associated with each cusp, called the sinuses of Valsalva or aortic sinuses, and their association with the respective coronary ostia identifies them: left, right, and non-coronary sinuses. Each cusp is attached to the wall of the aorta by the outward edges of its semicircular border, and the attachment point between each leaflet is called a commissure [PMID:24827036].</rdfs:comment>
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