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    <!-- http://purl.obolibrary.org/obo/HP_0004313 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0004313">
        <rdfs:label>Decreased circulating immunoglobulin concentration</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0010701"/>
        <dcterms:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2008-02-20T03:34:00Z</dcterms:date>
        <oboInOwl:hasExactSynonym>Immunoglobulin deficiency</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Decreased serum immunoglobulin</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Decreased circulating antibody level</oboInOwl:hasExactSynonym>
        <ns3:IAO_0000115>An abnormally decreased level of immunoglobulin in blood.</ns3:IAO_0000115>
        <oboInOwl:hasDbXref>SNOMEDCT_US:119250001</oboInOwl:hasDbXref>
        <rdfs:comment>In humans, immunoglobulins comprise the five antibody isotypes IgA, IgD, IgE, IgG and IgM.</rdfs:comment>
        <oboInOwl:hasDbXref>UMLS:C0086438</oboInOwl:hasDbXref>
        <oboInOwl:hasAlternativeId>HP:0010703</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>Hypogammaglobulinemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Reduced immunoglobulin levels</oboInOwl:hasExactSynonym>
        <oboInOwl:id>HP:0004313</oboInOwl:id>
        <oboInOwl:hasExactSynonym>Decreased antibody level in blood</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>UMLS:C4048270</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Decreased immunoglobulin level</oboInOwl:hasExactSynonym>
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