Abnormality of the endocrine system Abnormality of the pancreas Abnormality of the pancreatic islet cells 2008-03-28T04:41:00Z UMLS:C4025043 HP:0006476 An abnormality of the islet of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells. These are the alpha cells, which produce glucagon, the beta cells, which produce insulin and amylin, the delta cells, which produce somatostatin, the PP cells, which produce pancreatic polypeptide, and the epsilon cells, which produce ghrelin. HP:0100567