fibrosarcoma low grade fibromyxoid sarcoma ONCOTREE:LGFMS A low grade, late-metastasizing variant of fibrosarcoma characterized by alternating fibrous and myxoid areas and a whorling growth pattern. The neoplastic cells have a spindle morphology, and lack hyperchromasia or significant nuclear atypia. Approximately 40% of cases show the focal presence of collagen rosettes. A t(7;16)(q33;p11) translocation has been identified in the majority of cases, associated with the presence of FUS-CREB3L2 fusion protein. Rare cases carry the t(11;16)(p11;p11) translocation which is associated with the presence of the FUS-CREB3L1 fusion protein. low-grade fibromyxoid sarcoma UMLS:C1275282 SCTID:404088004 MONDO:0006272 GARD:0024355 NCIT:C45202 MEDGEN:224814 low grade fibromyxoid sarcoma ICD9:171.9