thumb stiffness-brachydactyly-intellectual disability syndrome https://www.malacards.org/card/thumb_stiffness_brachydactyly_intellectual_disability_syndrome https://www.malacards.org/card/thumbs_stiff_with_brachydactyly_type_a1_and_developmental_delay Thumb ankylosis with mental retardation Piussan-Lenaerts-Mathieu syndrome OMIM:188201 Orphanet:1078 thumbs, STIFF, with brachydactyly type A1 and developmental delay Thumb stiffness-brachydactyly-intellectual disability syndrome is characterized by intellectual deficit, mild dysmorphism, type A brachydactylia, signs of obesity and ankylosis of both thumbs. It has been reported in several females from one family (a girl and her mother, her grandmother and probably also her sister and her great-aunt), as well as in an isolated case. UMLS:C1861166 MEDGEN:396073 thumb stiff brachydactyly mental retardation MONDO:0008563 GARD:0004375 Thumb ankylosis with intellectual disability thumb stiff brachydactyly intellectual disability congenital limb malformation Thumb stiffness - brachydactyly - intellectual disability