syndromic intellectual disability hereditary disease agnathia-otocephaly complex https://github.com/monarch-initiative/mondo/issues/5588 https://www.malacards.org/card/agnathia_otocephaly_complex agnathia-holoprosencephaly-situs inversus syndrome OMIM:202650 MEDGEN:78541 agnathia-holoprosencephaly agnathia-otocephaly complex GARD:0009126 ICD9:759.89 Agnathia-holoprosencephaly-situs inversus syndrome is an extremely rare and fatal association syndrome, characterized by absence of the mandible, cerebral malformations with facial anomalies related to a defect in cleavage in the embryonic brain (e.g. synophthalmia, malformed and low-set ears fused in midline (otocephaly), agenesis of the olfactory bulbs, microstomia, hypoglossia/aglossia) and situs inversus partialis or totalis. AGOTC NCIT:C124568 otocephaly holoprosencephaly-agnathia Orphanet:990 UMLS:C0265242 dysgnathia complex agnathia-holoprosencephaly MONDO:0008740 DOID:0060341 SCTID:48180002 multiple congenital anomalies/dysmorphic syndrome-intellectual disability Agnathia - holoprosencephaly - situs inversus