arthrogryposis syndrome popliteal pterygium syndrome MESH:C562509 DOID:0060055 SCTID:66783006 PPS NCIT:C118786 icd11.foundation:543218573 Orphanet:294963 GARD:0021189 UMLS:C0265259 ICD9:756.89 MONDO:0017435 MEDGEN:78543 A rare, autosomal dominant inherited syndrome caused by mutations in the IRF6 gene. It is characterized by the presence of cleft palate, cleft lip, pits in the lower lip, web behind the knee (popliteal pterygium), syndactyly, cryptorchidism, scrotal malformation, and hypoplasia of the labia majora. IRF6-related condition obsolete_popliteal pterygium syndrome