typhus epidemic louse-borne typhus icd11.foundation:295798687 Orphanet:83314 typhus NCIT:C84689 MEDGEN:21744 epidemic typhus fever UMLS:C0041473 epidemic typhus MedDRA:10014979 DOID:0050480 epidemic louse-borne typhus A gram-negative bacterial infection caused by Rickettsia prowazekii. It is spread by lice infected with the bacteria. Signs and symptoms include sudden headache, generalized muscle pain, malaise, and macular skin lesions. The infection may affect the central nervous system causing encephalitis. MONDO:0019362 GARD:0019032