familial dilated cardiomyopathy mitochondrial oxidative phosphorylation disorder hereditary optic neuropathy Leber plus disease MONDO:0020478 Orphanet:99718 Leber `plus' disease describes patients with the clinical features of Leber's hereditary optic neuropathy (LHON) in combination with other serious systemic or neurological abnormalities. These abnormalities include: postural tremor, motor disorder, multiple sclerosis-like syndrome, spinal cord disease, skeletal changes, Parkinsonism with dystonia, anarthria, dystonia, motor and sensory peripheral neuropathy, spasticity and mild encephalopathy. It is caused by maternally-inherited mitochondrial DNA (mtDNA) mutations. MEDGEN:930394 GARD:0008476 SCTID:719430008 LHON plus disease DOID:0111754 UMLS:C4304725 obsolete_Leber plus disease