inborn errors of metabolism proteostasis deficiencies SQSTM1-related multisystem proteinopathy https://github.com/monarch-initiative/mondo/issues/6882 SQSTM1-related multisystem proteinopathy GARD:0026565 MONDO:0800464 A group of disorders including Paget disease of bone (PBD), inclusion body myopathy (IBM), and less frequently frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Phenotypic presentation and severity are highly variable, and individuals within the same family may present with different associated conditions.