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    <!-- http://www.ebi.ac.uk/efo/EFO_0000107 -->

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        <rdfs:label>obsolete_hypothalamus</rdfs:label>
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        <ns2:IAO_0000115>A basal part of the diencephalon that lies beneath the thalamus on each side, forms the floor of the third ventricle, and includes vital autonomic regulatory centers.nThe ventral part of the diencephalon that forms the floor and part of the lateral wall of the third ventricle. Anatomically, it includes the preoptic area, optic tract, optic chiasm, mammillary bodies, tuber cinereum, infundibulum, and neurohypophysis, but for physiological purposes the neurohypophysis is considered a distinct structure. The hypothalamus may be divided into five regions or areas (area hypothalamica rostralis, area hypothalamica dorsalis, area hypothalamica intermedia, area hypothalamica lateralis and area hypothalamica posterior) or into three longitudinal zones (periventricular zone, medial zone, and lateral zone). The hypothalamic nuclei constitute that part of the corticodiencephalic mechanism that activates, controls and integrates the peripheral autonomic mechanisms, endocrine activity, and many somatic functions, e.g., a general regulation of water balance, body temperature, sleep, and food intake, and the development of secondary sex characteristics. The hypothalamus secretes vasopressin and oxytocin, which are stored in the pituitary, as well as many releasing factors (hypophysiotropic hormones), by means of which it exerts control over functions of the adenohypophysis.</ns2:IAO_0000115>
        <oboInOwl:hasExactSynonym>Preoptico-hypothalamic region</oboInOwl:hasExactSynonym>
        <ns2:IAO_0000117>Tomasz Adamusiak</ns2:IAO_0000117>
        <oboInOwl:hasDbXref>ZFA:0000032</oboInOwl:hasDbXref>
        <ns2:IAO_0000115>Multi-tissue structure which is the largest portion of diencephalon and is ventrally located. The hypothalamus arises near the end of the segmentation period and the embryonic hypothalamic region gives rise to the neurohypophysis and other diencephalic nuclei.</ns2:IAO_0000115>
        <ns5:obsoleted_in_version>2.38</ns5:obsoleted_in_version>
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        <oboInOwl:hasExactSynonym>Preoptico-hypothalamic area</oboInOwl:hasExactSynonym>
        <ns2:IAO_0000117>James Malone</ns2:IAO_0000117>
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        <ns5:reason_for_obsolescence>Use http://purl.obolibrary.org/obo/UBERON_0001898
label: hypothalamus</ns5:reason_for_obsolescence>
        <oboInOwl:hasDbXref>MA:0000173</oboInOwl:hasDbXref>
        <ns2:IAO_0100001>http://purl.obolibrary.org/obo/UBERON_0001898</ns2:IAO_0100001>
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        <oboInOwl:hasExactSynonym>CNS - Brain - Hypothalamus (MMHCC)</oboInOwl:hasExactSynonym>
        <ns2:IAO_0000115>The ventral part of the diencephalon that forms the floor and part of the lateral wall of the third ventricle. Anatomically, it includes the preoptic area, optic tract, optic chiasm, mammillary bodies, tuber cinereum, infundibulum, and neurohypophysis, but for physiological purposes the neurohypophysis is considered a distinct structure. The hypothalamus may be divided into five regions or areas (area hypothalamica rostralis, area hypothalamica dorsalis, area hypothalamica intermedia, area hypothalamica lateralis and area hypothalamica posterior) or into three longitudinal zones (periventricular zone, medial zone, and lateral zone). The hypothalamic nuclei constitute that part of the corticodiencephalic mechanism that activates, controls and integrates the peripheral autonomic mechanisms, endocrine activity, and many somatic functions, e.g., a general regulation of water balance, body temperature, sleep, and food intake, and the development of secondary sex characteristics. The hypothalamus secretes vasopressin and oxytocin, which are stored in the pituitary, as well as many releasing factors (hypophysiotropic hormones), by means of which it exerts control over functions of the adenohypophysis.</ns2:IAO_0000115>
        <ns2:IAO_0000115>A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. Kimmel et al, 1995.</ns2:IAO_0000115>
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