obsolete_MELAS syndrome true 2.32 Tomasz Adamusiak OMIM:540000 true use 'http://www.orpha.net/ORDO/Orphanet_550' instead. New Label : MELAS syndrome http://www.orpha.net/ORDO/Orphanet_550 MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKE EPISODES Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117) James Malone Syndrome, MELAS MESH:D017241 DOID:3687 MELAS