<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/EFO?iri=http://www.ebi.ac.uk/efo/EFO_0000224"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:ns5="http://www.ebi.ac.uk/efo/"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:skos="http://www.w3.org/2004/02/skos/core#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/reason_for_obsolescence"/>
    <AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/obsoleted_in_version"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0100001"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#closeMatch"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#exactMatch"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://www.ebi.ac.uk/efo/EFO_0000224 -->

    <Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0000224">
        <rdfs:label>obsolete_acute promyelocytic leukemia</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</deprecated>
        <oboInOwl:hasRelatedSynonym>APL</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute promyelocytic leukemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute promyelocytic leukemia with t(15;17)(q22;q12); PML-rara</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>APML</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>ICD10:C92.40</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ICDO:9866/3</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>acute myeloblastic leukemia type 3</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>AML with t(15;17)(q22;q12)</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute myeloid leukemia M3</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>OMIM:612376</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GARD:0000538</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ICD10:C92.4</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MedDRA:10001019</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>DOID:0060318</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>APML - acute promyelocytic leukemia</oboInOwl:hasExactSynonym>
        <ns5:obsoleted_in_version>3.88.0</ns5:obsoleted_in_version>
        <oboInOwl:hasDbXref>Orphanet:520</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>acute promyelocytic leukemia with PML-rara</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute promyelocytic leukemia with t(15;17)(q22;q12); PML/rara</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute myeloblastic leukemia 3</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>leukemia, acute promyelocytic</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>promyelocytic leukemia</oboInOwl:hasExactSynonym>
        <ns5:reason_for_obsolescence>Replaced by Mondo term MONDO_0012883, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0012883</ns5:reason_for_obsolescence>
        <oboInOwl:hasDbXref>SCTID:110004001</oboInOwl:hasDbXref>
        <ns4:IAO_0100001>http://purl.obolibrary.org/obo/MONDO_0012883</ns4:IAO_0100001>
        <oboInOwl:hasDbXref>NCIT:C3182</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0000224</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:D015473</oboInOwl:hasDbXref>
        <ns4:IAO_0000115>Acute promyelocytic leukemia (APL) is an aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue.</ns4:IAO_0000115>
        <oboInOwl:hasExactSynonym>AML M3</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>FAB M3</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>UMLS:C0023487</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>AML with t(15;17)(q22;q12);(PML/RARalpha) and variants</oboInOwl:hasExactSynonym>
        <skos:exactMatch rdf:resource="http://identifiers.org/meddra/10001019"/>
        <skos:exactMatch rdf:resource="http://identifiers.org/mesh/D015473"/>
        <skos:exactMatch rdf:resource="http://identifiers.org/omim/612376"/>
        <skos:exactMatch rdf:resource="http://identifiers.org/snomedct/110004001"/>
        <skos:closeMatch rdf:resource="http://identifiers.org/snomedct/28950004"/>
        <skos:exactMatch rdf:resource="http://linkedlifedata.com/resource/umls/id/C0023487"/>
        <skos:exactMatch rdf:resource="http://purl.obolibrary.org/obo/DOID_0060318"/>
        <skos:exactMatch rdf:resource="http://purl.obolibrary.org/obo/NCIT_C3182"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#ordo_disease"/>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



