obsolete_acute quadriplegic myopathy true http://purl.obolibrary.org/obo/MONDO_0004969 The Sarcomere and Skeletal Muscle Diseases. Advances in Experimental Medicine and Biology Volume 642, 2008, pp92-98. Print ISBN:978-0-387-84846-4, Online ISBN:978-0-387-84847-1 Acute Quadriplegic Myopathy (AQM) is a specific acquired myopathy in ICU patients. Patients with AQM are characterized by severe muscle weakness and atrophy of spinal nerve innervated limb and trunk muscles, while cranial nerve innervated craniofacial muscles, sensory and cognitive functions are spared or less affected. The muscle weakness is associated with altered muscle membrane properties and a preferential loss of the motor protein myosin and myosin-associated thick filament proteins. Prolonged mechanical ventilation, muscle unloading, postsynaptic block of neuromuscular transmission, sepsis and systemic corticosteroid hormone treatment have been suggested as important triggering factors in AQM. NCIm:C1135345 James Malone 3.88.0 MONDO:0004969 Sirarat Sarntivijai ISBN:978-0-387-84847-1 ISBN:978-0-387-84846-4 Replaced by Mondo term MONDO_0004969, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0004969