obsolete_amyotrophic lateral sclerosis true true Sclerosis, Amyotrophic Lateral OMIM:105400 NIFSTD:birnlex_12566 Amyotrophic lateral sclerosis, Parkinsonism/Dementia complex of Guam MedDRA:10002026 GEHRIGS DIS Motor neuron disease, bulbar Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) MedDRA:10052889 Disease, Lou-Gehrigs Lou Gehrig's Disease OMIM:617921 Lou Gehrigs Disease James Malone ORDO:Orphanet_803 Lou Gehrig Disease Replaced with Mondo term see https://github.com/ebispot/efo/issues/1381 Amyotrophic Lateral Sclerosis, Guam Form DOID:332 MESH:D000690 OMIM:617892 Bulbar motor neuron disease An autosomal dominant inherited form of amyloidosis. Amyotrophic lateral sclerosis (disorder) OMIM:616208 ICD9:335.20 ALS Gehrigs Disease Gehrig Disease 3.38.0 OMIM:105500 SNOMEDCT:86044005 Guam Form of Amyotrophic Lateral Sclerosis Gautier Koscielny LOU GEHRIGS DIS ALS - Amyotrophic lateral sclerosis NCIt:C34373 Motor Neuron Disease, Amyotrophic Lateral Sclerosis MOTOR NEURON DIS AMYOTROPHIC LATERAL SCLEROSIS Lou-Gehrigs Disease LOU GEHRIG DIS OMIM:617839 Tomasz Adamusiak Charcot disease http://purl.obolibrary.org/obo/MONDO_0004976 AMYOTROPHIC SCLEROSIS Gehrig's Disease Dementia With Amyotrophic Lateral Sclerosis A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH). ALS (Amyotrophic Lateral Sclerosis) Lateral Scleroses, Amyotrophic Amyotrophic Lateral Sclerosis With Dementia