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    <!-- http://www.ebi.ac.uk/efo/EFO_0000367 -->

    <Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0000367">
        <rdfs:label>obsolete_common variable immunodeficiency</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
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        <ns2:IAO_0000117>Tomasz Adamusiak</ns2:IAO_0000117>
        <ns5:obsoleted_in_version>2.32</ns5:obsoleted_in_version>
        <oboInOwl:hasExactSynonym>Variable Hypogammaglobulinemias, Common</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Hypogammaglobulinemia, Common Variable</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Deficiencies, Late-Onset Immunoglobulin</oboInOwl:hasExactSynonym>
        <ns2:IAO_0000115>A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).</ns2:IAO_0000115>
        <oboInOwl:hasExactSynonym>COMMON VARIABL IMMUNODEF</oboInOwl:hasExactSynonym>
        <ns5:reason_for_obsolescence>use  &#39;http://www.orpha.net/ORDO/Orphanet_1572&#39; instead.
New Label : Common variable immunodeficiency</ns5:reason_for_obsolescence>
        <oboInOwl:hasExactSynonym>Variable Hypogammaglobulinemia, Common</oboInOwl:hasExactSynonym>
        <ns2:IAO_0000115>Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.</ns2:IAO_0000115>
        <oboInOwl:hasExactSynonym>Hypogammaglobulinemias, Acquired</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Late onset immunoglobulin deficiency</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>CVAG</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acquired hypogammaglobulinemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Sporadic hypogammaglobulinemia</oboInOwl:hasExactSynonym>
        <ns2:IAO_0000115>A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.</ns2:IAO_0000115>
        <oboInOwl:hasDbXref>OMIM:607594</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:D017074</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Hypogammaglobulinemias, Common Variable</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Immunoglobulin Deficiency, Late Onset</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>NCIt:C26725</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Common Variable Hypogammaglobulinemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Immunoglobulin Deficiency, Late-Onset</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Acquired hypogammaglobulinaemia</oboInOwl:hasExactSynonym>
        <ns2:IAO_0000117>James Malone</ns2:IAO_0000117>
        <oboInOwl:hasExactSynonym>Immunodeficiencies, Common Variable</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Late-Onset Immunoglobulin Deficiencies</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>CVID - Common variable immunodeficiency</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>IMMUNODEFIC COMMON VARIABLE</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>DOID:12177</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ICD9:279.06</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Common variable hypogammaglobulinaemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Common Variable Hypogammaglobulinemias</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>SNOMEDCT:23238000</oboInOwl:hasDbXref>
        <ns2:IAO_0100001>http://www.orpha.net/ORDO/Orphanet_1572</ns2:IAO_0100001>
        <oboInOwl:hasExactSynonym>Late-Onset Immunoglobulin Deficiency</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>CVID</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Common variable agammaglobulinemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Acquired Hypogammaglobulinemias</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Immunodeficiency, Common Variable</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>CVI - Common variable immunodeficiency</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>COMMON VARIABLE IMMUNODEFIC</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acquired Agammaglobulinemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Common Variable Immunodeficiencies</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Immunoglobulin Deficiencies, Late-Onset</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Deficiency, Late-Onset Immunoglobulin</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Common variable agammaglobulinaemia</oboInOwl:hasExactSynonym>
        <ns5:organizational_class>true</ns5:organizational_class>
        <oboInOwl:hasExactSynonym>Common variable agammaglobulinemia (disorder)</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Hypogammaglobulinemia, Acquired</oboInOwl:hasExactSynonym>
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