obsolete_brain tumor glioblastoma true A rare histological variant of glioblastoma (WHO grade IV) with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network, and a high frequency of TP53 mutations. (WHO) http://purl.obolibrary.org/obo/MONDO_0018177 1.5 duplication with glioblastoma (EFO_0000519) EFO:0000303 SNOMEDCT:44529004 NCIt:C4325 James Malone true MESH:D005909 A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures. DOID:3074