obsolete_glioblastoma multiforme true true Replaced by Mondo term MONDO_0018177, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0018177 ICD10:C71.9 ICDO:9440/3 gliosarcoma (histologic variant) GARD:0002491 UMLS:CN227279 glioblastoma (disease) grade IV astrocytoma WHO grade IV glioma glioblastoma (disease) HP:0100843 GBM (glioblastoma) NCIT:C3058 Orphanet:360 glioblastoma ONCOTREE:GBM DOID:3068 The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) grade IV adult astrocytic tumor MedDRA:10018337 MedDRA:10018336 3.88.0 http://purl.obolibrary.org/obo/MONDO_0018177 UMLS:C0017636 spongioblastoma multiforme primary glioblastoma multiforme GBM glioblastoma multiforme (disease) ONCOTREE:GB HP:0012174 giant cell glioblastoma (histologic variant) grade IV astrocytic tumor UMLS:C1621958 SCTID:393563007 glioblastoma multiforme grade IV astrocytic neoplasm