obsolete_Sjogren syndrome true true James Malone xerodermosteosis DOID:12894 Sjogren's syndrome (disorder) Sicca syndrome (disorder) Syndrome, Sjogren's Sicca syndrome SJOGREN'S SYNDROME Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis. An autoimmune disorder affecting the salivary and lacrimal glands. Morphologically, it is characterized by the presence of lymphocytic and plasmacytic infiltrates which cause destruction of these glands. It results in dry mouth and dry eyes. It may be associated with the presence of other autoimmune disorders, including rheumatoid arthritis and lupus erythematosus. An autoimmune disease that results_from attack of immune cells which destroy the exocrine glands that produce tears and saliva. Syndrome, Sicca http://purl.obolibrary.org/obo/MONDO_0010030 3.88.0 OMIM:270150 Tomasz Adamusiak Sjogrens Syndrome NCIt:C26883 Replaced by Mondo term MONDO_0010030, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0010030 Sjogren's disease MESH:D012859 Mikulicz disease Sjgren's syndrome (disorder) Sicca (Sjogren's) syndrome DOID:12900 ICD9:710.2