obsolete_anaplastic astrocytoma true http://purl.obolibrary.org/obo/MONDO_0016684 Orphanet:251589 ICDO:9401/3 MedDRA:10060971 NCIT:C9477 ICD10:C71.9 anaplastic astrocytoma DOID:3078 Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord. UMLS:C0334579 grade III astrocytic tumor grade III astrocytic neoplasm Replaced by Mondo term MONDO_0016684, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0016684 malignant astrocytoma astrocytoma, anaplastic, malignant grade III astrocytoma 3.88.0 EFO:0002499 ONCOTREE:AASTR GARD:0005860 MedDRA:10002224