obsolete_X-linked agammaglobulinemia true Bruton's type agammaglobulinemia http://www.orpha.net/ORDO/Orphanet_47 true DOID:14179 X-linked agammaglobulinemia (disorder) NCIt:C3822 A B cell deficiency that is caused by a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome resulting in X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Bruton's X-Linked Agammaglobulinemia Bruton's agammaglobulinaemia Tomasz Adamusiak X-linked agammaglobulinemia. An immunodeficiency state characterized (usually) by profoundly low concentrations of serum immunoglobulins of all classes, although occasionally significant amounts of one or more isotypes can be found. The fundamental defect in XLA affects early lineage B cells. use 'http://www.orpha.net/ORDO/Orphanet_47' instead. New Label : X-linked agammaglobulinemia 2.32 Bruton's Sex-Linked Agammaglobulinemia Bruton-type agammaglobulinemia Bruton agammaglobulinemia tyrosine kinase deficiency OMIM:300755 BTK deficiency