protein thrombin James Malone Thrombin is a "trypsin-like" serine protease protein that in humans is encoded by the F2 gene.[2][3] Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the coagulation cascade, which ultimately results in the stemming of blood loss. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. Ele Holloway http://en.wikipedia.org/wiki/Thrombin SNOMEDCT:36176003 MESH:D013917 Tomasz Adamusiak NCIt:C87773 OMIM:176930 DSSTox_Generic_SID:40626 SNOMEDCT:415715002