has_role tumor necrosis factor-alpha OMIM:191160 MESH:D014409 CASRN:308079-78-9 Tomasz Adamusiak TNF-alpha; tumor necrosis factor Tumor necrosis factor (TNF, cachexin or cachectin formerly known as tumor necrosis factor-alpha or TNF-α) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by other cell types as well. Ele Holloway DSSTox_CID:40634 http://en.wikipedia.org/wiki/Tumour_necrosis_factor-alpha James Malone cytokine cytokine role