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    <!-- http://www.ebi.ac.uk/efo/EFO_0003884 -->

    <Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0003884">
        <rdfs:label>obsolete_chronic kidney disease</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <ns2:gwas_trait rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</ns2:gwas_trait>
        <deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</deprecated>
        <oboInOwl:hasExactSynonym>END STAGE KIDNEY DIS</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>chronic kidney failure</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Kidney Insufficiencies, Chronic</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>MESH:D051436</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>SNOMEDCT:46177005</oboInOwl:hasDbXref>
        <ns3:IAO_0000115>Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)</ns3:IAO_0000115>
        <oboInOwl:hasDbXref>MESH:D007676</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Disease, End-Stage Renal</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Kidney Insufficiency, Chronic</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>MedDRA:10064848</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>RENAL DIS END STAGE</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>End-Stage Renal Failure</oboInOwl:hasExactSynonym>
        <ns2:obsoleted_in_version>3.88.0</ns2:obsoleted_in_version>
        <oboInOwl:hasExactSynonym>Renal Insufficiency, Chronic</oboInOwl:hasExactSynonym>
        <ns2:reason_for_obsolescence>Replaced by Mondo term MONDO_0005300, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0005300</ns2:reason_for_obsolescence>
        <oboInOwl:hasExactSynonym>End-Stage Kidney Disease</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Chronic Renal Failure</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>MedDRA:10038444</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>chronic renal insufficiency</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Renal Failure, End-Stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Chronic Kidney Insufficiencies</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>End Stage Renal Disease</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Kidney Disease, End-Stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>ICD9:585.6</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ICD10:N18</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>ESRD</oboInOwl:hasExactSynonym>
        <ns3:IAO_0000115>The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.</ns3:IAO_0000115>
        <oboInOwl:hasExactSynonym>Disease, End-Stage Kidney</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Chronic Kidney Insufficiency</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Kidney Failure, Chronic</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Renal Failure, End Stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>End-Stage Renal Disease</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Chronic Renal Insufficiencies</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Renal Disease, End Stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Renal Insufficiencies, Chronic</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>END STAGE RENAL DIS</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>SNOMEDCT:90688005</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>NCIt:C80078</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Renal Disease, End-Stage</oboInOwl:hasExactSynonym>
        <ns3:IAO_0100001>http://purl.obolibrary.org/obo/MONDO_0005300</ns3:IAO_0100001>
        <oboInOwl:hasDbXref>DOID:784</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>End Stage Kidney Disease</oboInOwl:hasExactSynonym>
        <ns3:IAO_0000117>Tomasz Adamusiak</ns3:IAO_0000117>
        <oboInOwl:hasExactSynonym>Renal Failure, Chronic</oboInOwl:hasExactSynonym>
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