<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/EFO?iri=http://www.ebi.ac.uk/efo/EFO_0004635"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:ns3="http://www.ebi.ac.uk/efo/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.ebi.ac.uk/efo/gwas_trait"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/IAO_0000136 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000136">
        <rdfs:label>is_about</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/MONDO_0011122 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/MONDO_0011122">
        <rdfs:label>obesity disorder</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/PR_000001875 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/PR_000001875">
        <rdfs:label>leptin receptor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/PR_000009758 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/PR_000009758">
        <rdfs:label>leptin</rdfs:label>
    </Class>
    


    <!-- http://www.ebi.ac.uk/efo/EFO_0004635 -->

    <Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0004635">
        <rdfs:label>leptin receptor measurement</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0004730"/>
        <rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0004747"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001875"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Class>
                <intersectionOf rdf:parseType="Collection">
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/MONDO_0011122"/>
                    </Restriction>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000009758"/>
                    </Restriction>
                </intersectionOf>
            </Class>
        </rdfs:subClassOf>
        <ns3:gwas_trait rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</ns3:gwas_trait>
        <oboInOwl:hasExactSynonym>soluble leptin receptor levels</oboInOwl:hasExactSynonym>
        <ns4:IAO_0000117>Helen Parkinson</ns4:IAO_0000117>
        <ns4:IAO_0000115>is a quantification of circulating soluble leptin receptor levels, these are inversely associated with diabetes risk factors, including adiposity and insulin resistance, and highly correlated with the expression levels of leptin receptor. Variations in the leptin receptor gene are reported to be associated with obesity.</ns4:IAO_0000115>
        <oboInOwl:hasExactSynonym>leptin receptor levels</oboInOwl:hasExactSynonym>
    </Class>
    


    <!-- http://www.ebi.ac.uk/efo/EFO_0004730 -->

    <Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0004730">
        <rdfs:label>hormone measurement</rdfs:label>
    </Class>
    


    <!-- http://www.ebi.ac.uk/efo/EFO_0004747 -->

    <Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0004747">
        <rdfs:label>protein measurement</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



