obsolete_Tourette syndrome true true Replaced by Mondo term MONDO_0007661, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0007661 OMIM:137580 MESH:D005879 Tourette's syndrome A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a general medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79) http://purl.obolibrary.org/obo/MONDO_0007661 NCIt:C35078 MedDRA:10044125 3.88.0 Helen Parkinson