obsolete_NUT midline carcinoma true nuclear protein in testis midline carcinoma A rare, highly aggressive and lethal carcinoma that affects children and young adults. It arises from midline epithelial structures, most commonly the head, neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) is present that results in the creation of a fusion gene involving the NUT gene, most commonly BRD4-NUT fusion gene. NMC NUT midline carcinoma of the head and neck UMLS:C1707291 EFO:0005783 Wikipedia:NUT_midline_carcinoma DOID:0060463 NUT carcinoma Midline carcinoma of children and Young adults with NUT rearrangement Replaced by Mondo term MONDO_0005563, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0005563 NCIT:C45716 NUT Midline carcinoma ICD10:C80.9 UMLS:CN237663 http://purl.obolibrary.org/obo/MONDO_0005563 Orphanet:443167 nut midline carcinoma ONCOTREE:NMCHN 3.88.0 carcinoma with t(15;19)(q13;p13.1) translocation