part_of part of part of is_input_of is specified input of bearer_of has characteristic has_quality has quality has quality derives_from chronic myelogenous leukemia, BCR-ABL1 positive Homo sapiens male bone marrow cell type Homo sapiens cell line ENCODE functional genome mapping ENCODE cell line chronic myelogenous leukemia cell line KBM-7 RRID:CVCL_A426 Catherine Leroy KBM-7 cells were derived from a 39-year-old man with chronic myeloid leukemia in blast crisis. The original cell line contained both near haploid and hyperdiploid clones. Subsequent subcloning yielded a pure near-haploid cell line.Genome analysis has revealed that besides the disomic chromosome 8 also a 30 megabase fragment of chromosome 15 is present in two copies. Like other CML cells lines (e.g., K562) KBM-7 cells are positive for the Philadelphia chromosome harboring the BCR-ABL oncogenic fusion. KBM-7 cells have been reprogrammed to yield the HAP1 cell line which is also haploid for chromosome 8. BTO:0005775 PMID:3466682