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    <!-- http://www.ebi.ac.uk/efo/EFO_0003740 -->

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    <!-- http://www.ebi.ac.uk/efo/EFO_0007692 -->

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        <ns3:IAO_0000115>5C stands for &quot;Chromosome conformation capture carbon copy&quot;. It is an extension of the original 3C technique that studies 3-dimensional organisation and interaction of chromatin in a cell. It detects interactions among all loci by ligating universal primers to all fragments. As a result, the whole genome is covered, albeit at a relatively low coverage. The 5C technique overcomes the junctional problems at the intramolecular ligation step and is useful for constructing complex interactions of specific loci of interest. </ns3:IAO_0000115>
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