response to antidepressant response to norepinephrine-dopamine reuptake inhibitor true Dani Welter Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine-dopamine reuptake inhibitor stimulus. Norepinephrine–dopamine reuptake inhibitors (NDRI) are a class of drugs that act as a reuptake inhibitor for the neurotransmitters norepinephrine and dopamine by blocking the action of the norepinephrine transporter (NET) and the dopamine transporter (DAT), respectively. This in turn leads to increased extracellular concentrations of both norepinephrine and dopamine and, therefore, an increase in adrenergic and dopaminergic neurotransmission.