Abnormality of metabolism/homeostasis gangrene true Death of tissue, usually in considerable mass and generally associated with loss of vascular (nutritive) supply and followed by bacterial invasion and putrefaction. [ NCI ] ICD10:R02 UMLS:C0017086 Zoe May Pendlington NCIt:C50573 MESH:D005734 MedDRA:10017711 HP:0100758