Autosomal recessive spastic paraplegia type 76 SPG76 OMIM:616907 Spastic paraplegia-76 is an autosomal recessive neurologic disorder characterized by young-adult onset of slowly progressive spasticity of the lower limbs resulting in gait difficulties. Most affected individuals have upper limb involvement and additional features such as foot deformities and dysarthria. Cognition is unaffected (summary by Gan-Or et al., 2016). Orphanet:488594 Hannah McLaren Spastic paraplegia-optic atrophy-neuropathy syndrome