Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome A rare autosomal dominant syndromic intellectual disability syndrome characterized by macrocephaly, seizures, umbilical hernia, and facial dysmorphic features including frontal bossing, midface hypoplasia, small chin, hypertelorism with downslanting palpebral fissures, depressed nasal bridge, smooth philtrum, and thin upper lip (Smith et al., 2013; Baynam et al., 2015). Orphanet:457485 Hannah McLaren MINDS syndrome Smith-Kingsmore syndrome OMIM:616638 Rare genetic developmental defect during embryogenesis