mutyh-associated polyposis Hannah McLaren MYH-Associated Polyposis MUTYH-Associated Polyposis MAP An autosomal recessive hereditary neoplastic syndrome caused by mutations in the MUTYH gene on chromosome 1p34.1. It is characterized by the presence of multiple colorectal polyps that may progress to carcinoma. Development of gastric and small intestinal polyps may also occur. NCIt:C96520 Genetic intestinal disease