IP-seq ligation-mediated chromosome conformation capture assay PLAC-seq Dani Welter PLAC-seq (proximity ligation-assisted ChIP-seq) is similar to a Hi-C assay, but following proximity ligation, immunoprecipitation is performed using an antibody to a transcription factor or histone modification. This results in a Hi-C library enriched for a specific DNA-protein interaction. This procedure differs from ChIA-PET in that the proximity ligation step is performed prior to chromatin shearing and immunoprecipitation.