autosomal recessive disease disorder of GPI anchor biosynthesis glycosylphosphatidylinositol biosynthesis defect 21 An autosomal recessive disorder characterized by global developmental delay, severe-to-profound intellectual disability, muscular hypotonia, seizures, brain anomalies, including thin corpus callosum and cerebellar atrophy, scoliosis, and mild facial dysmorphism. neurodevelopmental disorder with brain anomalies, seizures, and scoliosis paola OMIM:618590 Disorder of lipid metabolism