is_about breast cancer ovarian cancer carrier status BRCA1 mutation carier status true Elizabeth Lewis BRCA1 carrier status BRCA1 mutation status Determination of the presence or absence of known harmful mutation(s) in the BRAC1 gene. BRCA1/BRCA2 genes play a central role in DNA repair and their mutations increase sensitivity to DNA-damaging agents. BRCA1/BRCA2 germline mutations significantly increase the risk of breast and ovarian cancer. PMID:33597508