hepatobiliary disorder hepatotoxicity liver toxicity Toxicity that causes injury to the liver or impairs the liver function. Usually caused by exposure to xenobiotics such as drugs, food additives, alcohol, chlorinated solvents, peroxidized fatty acids, fungal toxins, radioactive isotopes, environmental toxicants, and some medicinal plants. This can include cholestasis, liver injury, hepatitis, jaundice. drug induced liver injury hepatic injury MESH:D056486 MedDRA:10019851 toxicity